When feeling the pinch, nuclei instigate cells to escape crowded spaces

When feeling the pinch, nuclei instigate cells to escape crowded spaces
The threat of serious deformation triggers a rapid escape reflex that enables cells to move away and squeeze out of tight spaces or crowded tissues.

In a new study published in the journal Science, researchers from CRG and ICFO reveal that squeezing a cell to the point where its nucleus starts to stretch triggers the activation of motor proteins which in turn transform the cell’s cytoskeleton so that it can flee a packed environment.”

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Welcome Alfonso Martínez Arias to the CATCAT network!

Dr. Martínez Arias joined the UPF Department of Experimental and Health Sciences as an ICREA senior research professor earlier this year. He has made outstanding contributions in the molecular underpinning of cell fate heterogeneity and self-organization properties of cell behaviour during development. We are pleased

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