When feeling the pinch, nuclei instigate cells to escape crowded spaces
The threat of serious deformation triggers a rapid escape reflex that enables cells to move away and squeeze out of tight spaces or crowded tissues.
In a new study published in the journal Science, researchers from CRG and ICFO reveal that squeezing a cell to the point where its nucleus starts to stretch triggers the activation of motor proteins which in turn transform the cell’s cytoskeleton so that it can flee a packed environment.”
