When feeling the pinch, nuclei instigate cells to escape crowded spaces

When feeling the pinch, nuclei instigate cells to escape crowded spaces
The threat of serious deformation triggers a rapid escape reflex that enables cells to move away and squeeze out of tight spaces or crowded tissues.

In a new study published in the journal Science, researchers from CRG and ICFO reveal that squeezing a cell to the point where its nucleus starts to stretch triggers the activation of motor proteins which in turn transform the cell’s cytoskeleton so that it can flee a packed environment.”

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